Activity-based MAP3K7/MAP3K7IP1 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
MAP3K7/MAP3K7IP1
Enzyme
Human MAP3K7/MAP3K7IP1, wt
HGNC
MAP3K7-TAB1
Manning ID
TAK1
Synonym
TAK1, TGF1a, MEKK7, TGF1a, MAP3K7, MAP3K7/MAP3K7IP1
UniProt
O43318 (M3K7_HUMAN)
Kinase Type
Protein kinase
Kinase Group
STE
Assay Properties
Assay Format
33PanQinaseTM
Substrates
RB-S6P, ATP
Reaction
RB-S6P + 33P-ATP = 33P-RB-S6P + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 19 |
| Sorafenib | 1500 |
| Sunitinb | 160 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | MAP3K7/MAP3K7IP1 |
| 345 wt Profiler | Yes |
| 345 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein |
No |
| Product Number | N/A |
| Web Shop | Reaction Biology Online Shop |
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