Activity-based KAT6B/MYST4 Histone Acetyltransferase Assay for compound screening and profiling via radiometric HAT assay.
Target Overview
CAT#
KAT6B/MYST4
Enzyme
Human KAT6B/MYST4
Synonyms
Histone acetyltransferase KAT6B, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4, Monocytic leukemia zinc finger protein-related factor, KIAA0383, MORF, MOZ2
Scientific Information
Q8WYB5 (http://www.uniprot.org/uniprot/Q8WYB5)
Assay Properties
Substrates
Histone H4, 2.5 μM
Acetyl CoA, 0.5 μM
Reaction
[Acetyl-³H]-Acetyl Coenzyme A + histone L-lysine = Coenzyme A + [Acety-³H]-L-lysine
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| WM-8014 | >10,000 |
| WM-3835 | 2260 |
| PF-9363 | 23.6 |
| WM-1119 | 1,000 |
| Anacardic Acid | 10,000 |
| Garcinol | 17,500 |
| Curcumin | 14,000 |
| C646 | 7,700 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Histone Acetyltransferase Assay (HAT) Services for Drug Discovery
Reference Compound IC50 for KAT6B/MYST4
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