Factor XIIa Protease Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
Factor XIIa
Enzyme
Coagulation factor XIIa
Synonym
Coagulation factor XII, Coagulation factor XIIa heavy chain, Beta-factor XIIa
Substrates
Fluorogenic substrate PFR-AMC, 50 µM
Assay Properties
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (µM) |
|---|---|
| Nafamostat Mesylate | 0.03 |
| Gabexate Mesylate | 0.25 |
| Leupeptin | 12.2 |
Scientific Information
P00748 (http://www.uniprot.org/uniprot/P00748)
Screening Location
Malvern, USA
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