Tissue Plasminogen Activator Protease Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
tPA
Enzyme
Tissue Plasminogen Activator
Synonym
Tissue-type plasminogen activator, tPA, Alteplase, Reteplase
Substrates
Fluorogenic substrate Z-GPR-AMC, 50 μM
Assay Properties
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (μM) |
|---|---|
| Nafamostat Mesylate | 0.37 |
| Gabexate Mesylate | 1.85 |
| Leupeptin | 57.99 |
Scientific Information
P00750 (http://www.uniprot.org/uniprot/P00750)
Screening Location
Malvern, USA
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