PDE7B Phosphodiesterase Assay for compound screening and profiling via fluorescence polarization-based quantification of enzyme activity.
Target Overview
CAT#
PDE7B
Enzyme
Human PDE7B
Synonym
cAMP-specific 3′,5′-cyclic phosphodiesterase 7B
Scientific Information
Q9NP56 (http://www.uniprot.org/uniprot/Q9NP56)
Assay Properties
Substrate
0.2 µM cAMP
Reaction
Nucleoside 3′,5′-cyclic phosphate + H₂O = nucleoside 5′-phosphate
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (µM) |
|---|---|
| BRL-50481 | >100 |
| TC-E 5005 | 20.6 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website PDE Assay Services
Reference Compound IC50 for PDE7B
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