HDAC7 Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
HDAC7
Enzyme
Human HDAC7
Synonyms
Histone deacetylase 7a, HDAC7A, Class IIa
Substrates
Fluorogenic HDAC Class2a Substrate (Boc-Lys(trifluoroacetyl)-AMC), 50 μM
Assay Properties
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| Trichostatin A | 4,000 |
| SAHA | 105,000 |
| TMP269 | 66 |
Scientific Information
Q8WUI4 (http://www.uniprot.org/uniprot/Q8WUI4)
Screening Location
Malvern, USA
Reference Compound IC50 for HDAC7
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