HDAC8 Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
HDAC8
Enzyme
Human HDAC8
Synonyms
Histone Deacetylase 8, Class I
Substrates
Fluorogenic peptide from p53 residues 379-382 (RHKAcKAc), 50 μM
Assay Properties
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| Trichostatin A | 440 |
| SAHA | 306 |
Scientific Information
Q9BY41 (http://www.uniprot.org/uniprot/Q9BY41)
Screening Location
Malvern, USA
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