Activity-based KIF2C Kinesin ATPase assay for compound screening and profiling via ADP-Glo™.
Target Overview
CAT#
KIF2C
Enzyme
Human KIF2C (182-646aa)
Family
Kinesin-13
Synonym
MCAK, KNSL6
Scientific Information
Q99661 (http://www.uniprot.org/uniprot/Q99661)
Assay Properties
Substrates
Tubulin Microtubules, 0.1 mg/ml
ATP, 10 µM
ATP, 10 µM
Reaction
ATP = ADP + Pi
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (µM) |
|---|---|
| Paprotrain | 35 |
| BTB-1 | >100 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Kinesin ATPase Assay Services
Reference compound inhibition of KIF2C
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