ACC1 Carboxylase Assay for compound screening and profiling via ADP-Glo based quantification of enzyme activity.
Target Overview
CAT#
ACC1
Synonyms
Acetyl-CoA carboxylase 1, ACACA, ACC-alpha, Biotin carboxylase
Enzyme
Human ACC1
Substrate
Acetyl-CoA, 10 μMATP 10 μM
Assay Properties
Reaction
Acetyl-CoA + ATP + HCO₃⁻ = Malonyl-CoA + ADP + Pi
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| CP 640186 | 1,950 |
| ACC2 Inhibitor | 12,600 |
Scientific Information
Q13085 (http://www.uniprot.org/uniprot/Q13085)
Compound IC50 for ACC1
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