Activity-based ACVR1 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
ACVR1
Enzyme
Human ACVR1, wt
HGNC
ACVR1
Manning ID
ALK2
Synonym
ACTRI, ACVRLK2, ALK2, SKR1, ACVR1, ACV-R1, ALK2/ACVR1
UniProt
Q04771 (ACVR1_HUMAN)
Kinase Type
Protein kinase
Kinase Group
TK
Assay Properties
Assay Format
33PanQinaseTM
Substrates
RBER-GSK3(14-27), ATP
Reaction
RBER-GSK3(14-27) + 33P-ATP = 33P-RBER-GSK3(14-27) + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 197 |
| Sorafenib | 10000 |
| Sunitinb | 6500 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | ACVR1 |
| 355 wt Profiler | Yes |
| 355 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein | Yes; ProQinaseTM – ACVR1 (Activity verified by 33PanQinaseTM-Assay) |
| Product Number | 0372-0000-1 |
| Web Shop | Reaction Biology Online Shop |
PDF