ALK Kinase Assay Service

Activity-based ALK kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
ALK
Enzyme
Human ALK
HGNC
ALK
Synonym
CD246, NBLST3
Substrates
Peptide substrate, poly[Glu:Tyr] (4:1), 0.2 mg/ml
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
Scientific Information
Q9UM73 (http://www.uniprot.org/uniprot/Q9UM73)
Screening Location
Malvern, USA
Reference compound IC50 for ALK