BACE 1 Protease Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
BACE 1
Enzyme
Human BACE 1
Synonym
Beta-secretase 1, Aspartyl protease 2, Beta-site amyloid precursor protein cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE, KIAA1149
Substrates
Fluorogenic peptide MCA-SEVNLDAEFRK(Dnp)-RR-NH2, 10 µM
Assay Properties
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| b-Secretase inhibitor IV | 187 |
Scientific Information
P56817 (https://www.uniprot.org/uniprotkb/P56817/entry)
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Protease Assay Services.
Reference compound IC50 for BACE 1
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