c-MER Kinase Assay Service - Reaction Biology

Activity-based c-MER kinase assay for compound screening and profiling via radiometric HotSpot^TM kinase assay.

Target Overview

CAT#

c-MER

Enzyme

Human c-MER

HGNC

MERTK

Synonym

MER, MER-PEN, RP38

Substrates

Peptide substrate, poly[Glu:Tyr] (4:1), 0.1 mg/ml
ATP 10 µM

Assay Properties

Reaction

Substrate + [γ-³³P]-ATP = ³³P-Substrate + ADP

Readout

Enzymatic activity

Reference Compound IC50s

Scientific Information

Q12866 (http://www.uniprot.org/uniprot/Q12866)

Screening Location

Malvern, USA

Reference compound IC50 for c-MER