Activity-based CCDC6 RET kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
CCDC6 RET
Enzyme
Human CCDC6 RET, mutant
HGNC
RET-CCDC6
Manning ID
RET
Synonym
CCDC6-RET, CCDC6-RETa, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, CCDC6 RET, RET-CCDC6 (PTC1)
UniProt
Q06187 (BTK_HUMAN)
Kinase Type
Protein kinase
Kinase Group
TK
Assay Properties
Assay Format
33PanQinaseTM
Substrates
PolyEY, ATP
Reaction
PolyEY+ 33P-ATP = 33P-PolyEY + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 22 |
| Sorafenib | 320 |
| Sunitinb | 20 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | CCDC6 RET |
| 345 wt Profiler | No |
| 345 IC50 wt Profiler | No |
| Mutant Profiler Addon | Yes |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein |
Yes; ProQinaseTM – CCDC6 RET |
| Product Number |
1417-0000-1 |
| Web Shop | Reaction Biology Online Shop |
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