Activity-based CDK11B/CycK kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
CDK11B/CycK
Enzyme
Human CDK11B/CycK, wt
HGNC
CDK11B-CCNK
Manning ID
PITSLRE
Synonym
CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, PK58, p58CDC2L1, p58CLK-1;CDC2L1, CDK11B, CDC2L1; PITSLRE
UniProt
P21127 (CDK11B_HUMAN)
Kinase Type
Protein kinase
Kinase Group
CMGC
Assay Properties
Assay Format
33PanQinaseTM
Substrates
SUPT5 754-837, ATP
Reaction
SUPT5 754-837 + 33P-ATP = 33P-SUPT5 754-837 + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Sorafenib | 100000 |
| Sunitinib | 55000 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | CDK11B/CycK |
| 355 wt Profiler | Yes |
| 355 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | IC50 CDK Profiler |
Recombinant Protein Availability
| Active recombinant protein | No |
| Product Number | N/A |
| Web Shop | Reaction Biology Online Shop |
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