Activity-based CDK13/CycK kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
CDK13/CycK
Enzyme
Human CDK13/CycK, wt
HGNC
CDK13-CCNK
Manning ID
CHED
Synonym
CDC2L, CDC2L5, KIAA1791, CDK13, CHED, CDK13/CycK, CDK13/cyclin K
UniProt
Q14004 (CDK13_HUMAN)
Kinase Type
Protein kinase
Kinase Group
CMGC
Assay Properties
Assay Format
33PanQinaseTM
Substrates
SUPT5 754-837, ATP
Reaction
SUPT5 754-837 + 33P-ATP = 33P-SUPT5 754-837 + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 104 |
| Sorafenib | 100000 |
| Sunitinb | 100000 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | CDK13/CycK |
| 345 wt Profiler | Yes |
| 345 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | IC50 CDK Profiler |
Recombinant Protein Availability
| Active recombinant protein | Yes; ProQinaseTM – CDK13/CycK (Activity verified by 33PanQinaseTM-Assay) |
| Product Number | 1530-1484-1 |
| Web Shop | Reaction Biology Online Shop |
PDF