CDK13/cyclin K Kinase Assay Service

Activity-based CDK13/cyclin K kinase assay for compound screening and profiling via radiometric HotSpot^TM kinase assay.

Target Overview

CAT#

CDK13/Cyclin K

Enzyme

Human CDK13/Cyclin K

HGNC

CDK13/CCNK

Synonym

CDC2L, CDC2L5, CHED

Substrates

Protein substrate, Pol2-CTD, 5 µM
ATP 10 µM

Assay Properties

Reaction

Substrate + [γ-³³P]-ATP = ³³P-Substrate + ADP

Readout

Enzymatic activity

Reference Compound IC50s

Scientific Information

CDK13: Q14004 (http://www.uniprot.org/uniprot/Q14004)Cyclin K: O75909 (http://www.uniprot.org/uniprot/O75909)

Screening Location

Malvern, USA

Reference compound IC50 for CDK13/cyclin K