CDK14/cyclin Y (PFTK1) Kinase Assay Service

Activity-based CDK14/cyclin Y (PFTK1) kinase assay for compound screening and profiling via radiometric HotSpot^TM kinase assay.

Target Overview

CAT#

CDK14/Cyclin Y

Enzyme

Human CDK14/Cyclin Y

HGNC

CDK14/CCNY

Synonym

PFTAIRE1, PFTK1

Substrates

RB protein, 3 µM
ATP 10 µM

Assay Properties

Reaction

Substrate + [γ-³³P]-ATP = ³³P-Substrate + ADP

Readout

Enzymatic activity

Reference Compound IC50s

Scientific Information

CDK14: O94921 (http://www.uniprot.org/uniprot/O94921)Cyclin Y: Q8ND76 (http://www.uniprot.org/uniprot/Q8ND76)

Screening Location

Malvern, USA

Reference compound IC50 for CDK14 (PFTK1)/cyclin Y