Activity-based CDK16/CycY kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
CDK16/CycY
Enzyme
Human CDK16/CycY, wt
HGNC
CDK16-CCNY
Manning ID
PCTAIRE1
Synonym
PCTAIRE, PCTGAIRE, PCTK1, CDK16, PCTAIRE1, CDK16/CycY, CDK16/cyclin Y
UniProt
Q00536 (CDK16_HUMAN)
Kinase Type
Protein kinase
Kinase Group
CMGC
Assay Properties
Assay Format
33PanQinaseTM
Substrates
RBER-GSK3(14-27), ATP
Reaction
RBER-GSK3(14-27) + 33P-ATP = 33P-RBER-GSK3(14-27) + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 36 |
| Sorafenib | 10000 |
| Sunitinib | 2900 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | CDK16/CycY |
| 355 wt Profiler | Yes |
| 355 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | IC50 CDK Profiler |
Recombinant Protein Availability
| Active recombinant protein | Yes; ProQinaseTM – CDK16/CycY (Activity verified by 33PanQinaseTM-Assay) |
| Product Number | 1117-1116-1 |
| Web Shop | Reaction Biology Online Shop |
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