CDK2/cyclin O Kinase Assay Service

Activity-based CDK2/cyclin O kinase assay for compound screening and profiling via radiometric HotSpot^TM kinase assay.

Target Overview

CAT#

CDK2/Cyclin O

Enzyme

Human CDK2/Cyclin O

HGNC

CDK2/CCNO

Synonym

p33

Substrates

Histone H1, 20 µM
ATP 10 µM

Assay Properties

Reaction

Substrate + [γ-³³P]-ATP = ³³P-Substrate + ADP

Readout

Enzymatic activity

Reference Compound IC50s

Scientific Information

CDK2: P24941 (http://www.uniprot.org/uniprot/P24941)Cyclin O: P22674 (http://www.uniprot.org/uniprot/P22674)

Screening Location

Malvern, USA

Reference compound IC50 for CDK2/cyclin O