CYP4A11 for compound screening and profiling assay using luminescent based method to measure cytochrome P450 enzyme activity.
Target Overview
CAT#
CYP4A11
Enzyme
Human CYP4A11
Synonym
CYP4A2, CP4AB, 20-hydroxyeicosatetraenoic acid synthase, Human CYP4A11, Cytochrome P-450HK-omega, Cytochrome P450HL-omega, Fatty acid omega-hydroxylase
Scientific Information
Q02928 (https://www.uniprot.org/uniprotkb/Q02928)
Assay Properties
Substrate
P450-Glo™ proluciferin Substrate
Reaction
RH + O₂ + NADPH + H⁺ = ROH + H₂O + oxidized [NADPH—hemoprotein reductase]
Readout
Enzymatic activity
Reference Compound IC50s
| Compound | IC50 (nM) |
|---|---|
| HET0016 | 7.2 |
| TP0472993 | 112 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website CYP450 Inhibition Assay Services.
Reference compound IC50 for CYP4A11
