Activity-based ERK7 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
ERK7
Enzyme
Human ERK7, wt
HGNC
MAPK15
Manning ID
Erk7
Synonym
ERK7, ERK8, MAPK15, ERK7/MAPK15
UniProt
Q8TD08 (MK15_HUMAN)
Kinase Type
Protein kinase
Kinase Group
CMGC
Assay Properties
Assay Format
33PanQinaseTM
Substrates
RBER-CHKtide, ATP
Reaction
RBER-CHKtide + 33P-ATP = 33P-RBER-CHKtide + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 20 |
| Sorafenib | 560 |
| Sunitinb | 2700 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | ERK7 |
| 345 wt Profiler | Yes |
| 345 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein |
Yes; ProQinaseTM – ERK7 |
| Product Number | 1106-0000-2 |
| Web Shop | Reaction Biology Online Shop |
PDF