GRK5 Kinase Assay Service

Activity-based GRK5 kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
GRK5

Enzyme
Human GRK5

HGNC
GRK5

Synonym
GPRK5

Substrates
Casein, 1 mg/ml
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
Staurosporine 71
Ro 31-8220 480
H-89 53,000
Scientific Information
P34947 (http://www.uniprot.org/uniprot/P34947)

Screening Location
Malvern, USA

Reference compound IC50 for GRK5
Reference compound IC50 for GRK5

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