GRK6 Kinase Assay Service

Activity-based GRK6 kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
GRK6

Enzyme
Human GRK6

HGNC
GRK6

Synonym
GPRK6, FLJ32135

Substrates
Casein, 1 mg/ml
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
Staurosporine 46
Ro 31-8220 1,100
GW 5074 24,000
H-89 15,000
Scientific Information
P43250 (http://www.uniprot.org/uniprot/P43250)

Screening Location
Malvern, USA

Reference compound IC50 for GRK6
Reference compound IC50 for GRK6

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