Activity-based GSG2 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
GSG2
Enzyme
Human GSG2, wt
HGNC
GSG2
Manning ID
Haspin
Synonym
GSG2, Haspin
UniProt
Q8TF76 (HASP_HUMAN)
Kinase Type
Protein kinase
Kinase Group
Other
Assay Properties
Assay Format
33PanQinaseTM
Substrates
Histon H3 (1-34), ATP
Reaction
Histon H3 (1-34) + 33P-ATP = 33P-Histon H3 (1-34) + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 29 |
| Sorafenib | 10000 |
| Sunitinb | 2300 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | GSG2 |
| 345 wt Profiler | Yes |
| 345 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein |
Yes; ProQinaseTM – GSG2 |
| Product Number | 1319-0000-1 |
| Web Shop | Reaction Biology Online Shop |
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