Hepsin Protease Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
Hepsin
Enzyme
Human Serine Protease Hepsin
Synonym
Transmembrane protease serine 1, TMPRSS1, HPN
Substrates
Fluorogenic substrate Boc-QRR-AMC, 10 µM
Assay Properties
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| Camostat Mesylate | 5.57 |
| Gabexate Mesylate | 87.25 |
| Leupeptin | 82.99 |
Scientific Information
P05981 (http://www.uniprot.org/uniprot/P05981)
Screening Location
Malvern, USA
PDF