IRR/INSRR Kinase Assay Service

Activity-based IRR/INSRR kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview

CAT#
IRR/INSRR

Enzyme
Human IRR/INSRR

HGNC
INSRR

Synonym
IRR

Substrates
MBP (Myelin Basic Protein), 20 µM
ATP 10 µM

Assay Properties

Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP

Readout
Enzymatic activity

Reference Compound IC50s
Compounds IC50 (nM)
Staurosporine 9.8
PP2 32,000
D-64406 41,000
Scientific Information
P14616 (http://www.uniprot.org/uniprot/P14616)

Screening Location
Malvern, USA

Reference compound IC50 for IRR/INSRR
Reference compound IC50 for IRR/INSRR

PDF