Activity-based JNK2 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
JNK2
Enzyme
Human JNK2, wt
HGNC
MAPK9
Manning ID
JNK2
Synonym
JNK-55, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, p54aSAPK, MAPK9, JNK2-alpha2, SAPK, p54a, JNK-alpha2, JNK2
UniProt
P45984 (MK09_HUMAN)
Kinase Type
Protein kinase
Kinase Group
CMGC
Assay Properties
Assay Format
33PanQinaseTM
Substrates
ATF2, ATP
Reaction
ATF2 + 33P-ATP = 33P-ATF2 + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 2533 |
| Sorafenib | 3400 |
| Sunitinb | 73000 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | JNK2 |
| 345 wt Profiler | Yes |
| 345 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein |
Yes; ProQinaseTM – JNK2 |
| Product Number | 0459-0000-1 |
| Web Shop | Reaction Biology Online Shop |
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