Kallikrein 8 Protease Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
Kallikrein 8
Enzyme
Human Kallikrein 8
Species
Human
Synonym
KLK8, NRPN, PRSS19, TADG14, Neuropsin (NP), Ovasin, hK8
Scientific Information
O60259 (https://www.uniprot.org/uniprotkb/O60259)
Assay Properties
Substrate
Fluorogenic peptide Boc-Val-Pro-Arg-AMC, 10 µM
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| Gabexate Mesylate | 44 |
| Leupeptin | 102 |
| Camostat Mesylate | 4.2 |
| Nafamostat Mesylate | 1.8 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Protease Assay Services
Reference compound inhibition of Kallikrein 8
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