Activity-based KIF22 Kinesin ATPase assay for compound screening and profiling via ADP-Glo™.
Target Overview
CAT#
KIF22
Enzyme
Human KIF22 (5-378aa)
Family
Kinesin-10
Synonym
KID, KNSL4, Kinesin-like protein 4
Scientific Information
Q14807 (http://www.uniprot.org/uniprot/Q14807)
Assay Properties
Substrates
Tubulin Microtubules, 0.1 mg/ml
ATP, 10 µM
ATP, 10 µM
Reaction
ATP = ADP + Pi
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (µM) |
|---|---|
| Paprotrain | 38 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Kinesin ATPase Assay Services
Reference compound inhibition of KIF22
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