Activity-based KIF3C Kinesin ATPase assay for compound screening and profiling via ADP-Glo™.
Target Overview
CAT#
KIF3C
Enzyme
Human KIF3C (2-428aa)
Family
Kinesin-2
Synonym
Kinesin-like protein KIF3C
Scientific Information
O14782 (http://www.uniprot.org/uniprot/O14782)
Assay Properties
Substrates
Tubulin Microtubules, 0.1 mg/ml
ATP, 10 µM
ATP, 10 µM
Reaction
ATP = ADP + Pi
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (µM) |
|---|---|
| AZ82 | 29.5 |
| Paprotrain | >100 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Kinesin ATPase Assay Services
Reference compound inhibition of KIF3C
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