MCL1 Apoptosis Assay for compound screening and profiling using HTRF to measure compound binding to the target.
Target Overview
CAT#
MCL1
Enzyme
Human MCL1
Synonyms
Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, BCL2L3
Substrates
BAK peptide, 100 nM; or Noxa peptide, 50 nM
Assay Properties
Reaction
Competition binding assay with Bak or Noxa peptide in HTRF assay.
Reference Compound IC50s
Bak Peptide
Noxa Peptide
Scientific Information
Q07820 (http://www.uniprot.org/uniprot/Q07820)
Screening Location
Malvern, USA
BAK peptide displacement IC50 for MCL1
Noxa peptide displacement IC50 for MCL1
