mDGKZ Kinase Assay Service

Activity-based mDGKZ lipid kinase assay for compound screening and profiling via ADP-Glo kinase assay.

Target Overview
CAT#

mDGKZ

Enzyme

Mouse DGKZ

HGNC

DGKZ Mouse

Synonym

Diacylglycerol kinase zeta, DAG kinase zeta, Dgkz

Scientific Information

Q80UP3 (https://www.uniprot.org/uniprot/Q80UP3)

Assay Properties
Substrates

DLG (1, 2-Dilauroyl-sn-glycerol), 500 µM
ATP, 50 µM

Reaction

1,2-dilauroyl-sn-glycerol + ATP = 1,2-dilauroyl-sn-glycero-3-phosphate + ADP + H+

Detection

ADP-Glo Assay

Reference Compound IC50s
Compounds IC50 (nM)
DGK-IN-1 (CAS No: 2407892-34-4) 13.8
Screening Location

Malvern, PA, USA

Further Information

More information can be found on our website Kinase Assays

Reference compound IC50 for mDGKZ

Reference compound IC50 for mDGKZ