Activity-based KAT7/MYST2 Histone Acetyltransferase Assay for compound screening and profiling via radiometric HAT assay.
Target Overview
CAT#
KAT7/MYST2
Enzyme
Human KAT7/MYST2
Synonyms
Histone acetyltransferase MYST2, Histone acetyltransferase binding to ORC1 MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2, HBO1, HBOa
Scientific Information
O95251 (http://www.uniprot.org/uniprot/O95251)
Assay Properties
Substrates
Histone H3, 2.5 μM
Acetyl CoA, 0.5 μM
Reaction
[Acetyl-³H]-Acetyl Coenzyme A + histone L-lysine = Coenzyme A + [Acety-³H]-L-lysine
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| WM-8014 | 2,000 |
| WM-3835 | 700 |
| PF-9363 | 3,100 |
| WM-1119 | >10,000 |
| Anacardic Acid | 5,200 |
| Garcinol | 11,000 |
| Curcumin | 44,000 |
| C646 | 7,300 |
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Histone Acetyltransferase Assay (HAT) Services for Drug Discovery
Reference Compound IC50 for KAT7/MYST2
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