Activity-based p38beta kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
p38beta
Enzyme
Human p38beta, wt
HGNC
MAPK11
Manning ID
p38b
Synonym
p38-beta, P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta, p38b, MAPK11, p38beta, P38b/MAPK11
UniProt
Q15759 (MK11_HUMAN)
Kinase Type
Protein kinase
Kinase Group
CMGC
Assay Properties
Assay Format
33PanQinaseTM
Substrates
ATF2, ATP
Reaction
ATF2 + 33P-ATP = 33P-ATF2 + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Sorafenib | 410 |
| Sunitinib | 100000 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | p38beta |
| 355 wt Profiler | Yes |
| 355 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein | Yes; ProQinaseTM – p38beta (Activity verified by 33PanQinaseTM-Assay) |
| Product Number | 0455-0000-3 |
| Web Shop | Reaction Biology Online Shop |
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