PTPN7/LC-PTP Phosphatase Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
PTPN7/LC-PTP
Enzyme
Human PTPN7/LC-PTP
Synonyms
Tyrosine-protein phosphatase non-receptor type 7, Hematopoietic protein-tyrosine phosphatase, PTN7
Substrates
Fluorogenic substrate DiFMUP, 10 μM
Assay Properties
Reaction
Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| NSC-87877 | 1,700 |
| PHPS1 | 97 |
| PTP1B Inhibitor | 7,000 |
Scientific Information
P35236 (http://www.uniprot.org/uniprot/P35236)
Screening Location
Malvern, USA
Reference Compound IC50 for PTPN7/LC-PTP
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