PTPRB Phosphatase Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
PTPRB
Enzyme
Human PTPRB
Synonyms
Receptor-type tyrosine-protein phosphatase beta, Protein-tyrosine phosphatase beta, Vascular endothelial protein tyrosine phosphatase, VE-PTP
Substrates
Fluorogenic substrate DiFMUP, 10 μM
Assay Properties
Reaction
Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (μM) |
|---|---|
| PTP1B Inhibitor | 5.3 |
| NSC87877 | 9.1 |
| PHPS1 | 99 |
Scientific Information
P23467 (https://www.uniprot.org/uniprotkb/P23467)
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Phosphatase Assay Services for Drug Discovery
Reference Compound IC50 for PTPRB
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