PTPRJ/CD148 Phosphatase Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
PTPRJ/CD148
Enzyme
Human PTPRJ/CD148
Synonyms
Receptor-type tyrosine-protein phosphatase eta, Protein-tyrosine phosphatase eta, Protein-tyrosine phosphatase receptor type J, Density-enhanced phosphatase 1, DEP1
Substrates
Fluorogenic substrate DiFMUP, 10 μM
Assay Properties
Reaction
Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (μM) |
|---|---|
| PTP1B Inhibitor | 10.9 |
| NSC87877 | 30.2 |
Scientific Information
Q12913 (https://www.uniprot.org/uniprotkb/Q12913)
Screening Location
Malvern, PA, USA
Further Information
More information can be found on our website Phosphatase Assay Services for Drug Discovery
Reference Compound IC50 for PTPRJ/CD148
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