RET R813Q Kinase Activity Assay Service

Activity-based RET R813Q kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology

Target Overview
RBE Target ID

RET R813Q

Enzyme

Human RET R813Q, mutant

HGNC

RET (R813Q)

Manning ID

RET

Synonym

RET, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, RET-ELE1, RET R813Q, RET (R813Q)

UniProt

P07949 (RET_HUMAN)

Kinase Type

Protein kinase

Kinase Group

TK

Assay Properties
Assay Format

33PanQinaseTM

Substrates

PolyEY, ATP

Reaction

PolyEY+ 33P-ATP = 33P-PolyEY + ADP

Readout

Enzymatic activity

Technical Reference Compound IC50 value(s)
Compounds IC50 (nM)
Staurosporine 16
Sorafenib 18
Sunitinib 22
Screening Location

Freiburg, Germany

Further Information

More information can be found on our website Kinase Assays

Service and Product Availability
Screening Opportunities
FreeChoice RET R813Q
355 wt Profiler No
355 IC50 wt Profiler No
Mutant Profiler Addon Yes
Lipid Kinase Profiler Addon No
IC50 Profiler IC50 RET Profiler
Recombinant Protein Availability
Active recombinant protein Yes; ProQinaseTM – RET R813Q
(Activity verified by 33PanQinaseTM-Assay)
Product Number 1097-0000-1
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