Activity-based RET Y806H kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
RET Y806H
Enzyme
Human RET Y806H, mutant
HGNC
RET (Y806H)
Manning ID
RET
Synonym
RET, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, RET-ELE1, RET Y806H, RET (Y806H)
UniProt
P07949 (RET_HUMAN)
Kinase Type
Protein kinase
Kinase Group
TK
Assay Properties
Assay Format
33PanQinaseTM
Substrates
PolyEY, ATP
Reaction
PolyEY+ 33P-ATP = 33P-PolyEY + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 42 |
| Sorafenib | 870 |
| Sunitinib | 570 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | RET Y806H |
| 355 wt Profiler | No |
| 355 IC50 wt Profiler | No |
| Mutant Profiler Addon | Yes |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein | Yes; ProQinaseTM – RET Y806H (Activity verified by 33PanQinaseTM-Assay) |
| Product Number | 1378-0000-1 |
| Web Shop | Reaction Biology Online Shop |
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