Activity-based RPS6KA5 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
RPS6KA5
Enzyme
Human RPS6KA5, wt
HGNC
RPS6KA5
Manning ID
MSK1
Synonym
EC 2.7.11., MGC1911, MSK1, MSPK1, RLPK, RSKL, MSK1, RPS6KA5, EC 2.7.11, MSPK1, RSKL, MSK1/RPS6KA5
UniProt
O75582 (KS6A5_HUMAN)
Kinase Type
Protein kinase
Kinase Group
AGC
Assay Properties
Assay Format
33PanQinaseTM
Substrates
RBER-CHKtide, ATP
Reaction
RBER-CHKtide + 33P-ATP = 33P-RBER-CHKtide + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 110 |
| Sorafenib | 10000 |
| Sunitinib | 50000 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | RPS6KA5 |
| 355 wt Profiler | Yes |
| 355 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein | No |
| Product Number | N/A |
| Web Shop | Reaction Biology Online Shop |
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