SIRT5 Sirtuin Assay Services

SIRT5 Sirtuin Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
SIRT5
Enzyme
Human SIRT5 (NAD+-dependent enzyme)
Synonyms
NAD-dependent protein deacylase sirtuin-5, Regulatory protein SIR2 homolog 5, SIR2-like protein 5, SIR2L5, Class III HDAC)
Substrates
Fluorogenic peptide (Ac-Lys-succ-AMC), 50 μM
NAD+, 500 μM
Readout
Enzymatic activity
Reference Compound IC50s
CompoundsIC50 (μM)
Nicotinamide24.2
Scientific Information
Q9NXA8 (http://www.uniprot.org/uniprot/Q9NXA8)
Screening Location
Malvern, USA
Reference Compound IC50 for SIRT5
Reference Compound IC50 for SIRT5