Activity-based SNK kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
SNK
Enzyme
Human SNK, wt
HGNC
PLK2
Manning ID
PLK2
Synonym
SNK, PLK2
UniProt
Q9NYY3 (PLK2_HUMAN)
Kinase Type
Protein kinase
Kinase Group
Other (CAMK)
Assay Properties
Assay Format
33PanQinaseTM
Substrates
RBER-GSK3(14-27), ATP
Reaction
RBER-GSK3(14-27) + 33P-ATP = 33P-RBER-GSK3(14-27) + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 570 |
| Sorafenib | 34000 |
| Sunitinib | 64000 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | SNK |
| 355 wt Profiler | Yes |
| 355 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein | Yes; ProQinaseTM – SNK (Activity verified by 33PanQinaseTM-Assay) |
| Product Number | 0277-0000-1 |
| Web Shop | Reaction Biology Online Shop |
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