SP140-His Reader Domain Assay for compound screening and profiling using the AlphaScreen assay format to measure compound binding to the target.
Target Overview
CAT#
SP140-His
Enzyme
Human SP140-His
Synonyms
Nuclear body protein SP140, Lymphoid-restricted homolog of Sp100, LYSP100
Substrates
Histone H3 peptide (1-21) K9/14Ac
Assay Properties
Reaction
AlphaScreen Binding assay
Readout
Fluorescence
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| JQ-1 | 63,000 |
| SGC-CBP30 | 52,000 |
Scientific Information
Q13342 (http://www.uniprot.org/uniprot/Q13342)
Screening Location
Malvern, USA
Further information
More information can be found on our website Reader Domain Assay Services.
Reference Compound IC50 for SP140
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