Activity-based TBK1 kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
TBK1
Enzyme
Human TBK1, wt
HGNC
TBK1
Manning ID
TBK1
Synonym
CDC37, FLJ11330, HSPCA, HSPCB, IKBKG, NAK, T2K, TANK, TRAF2, TBK1
UniProt
Q9UHD2 (TBK1_HUMAN)
Kinase Type
Protein kinase
Kinase Group
Other
Assay Properties
Assay Format
33PanQinaseTM
Substrates
Casein, ATP
Reaction
Casein + 33P-ATP = 33P-Casein + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 6 |
| Sorafenib | 10000 |
| Sunitinb | 3100 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | TBK1 |
| 345 wt Profiler | Yes |
| 345 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein |
Yes; ProQinaseTM – TBK1 |
| Product Number |
0749-0000-1 |
| Web Shop | Reaction Biology Online Shop |
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