TMPRSS2 Protease Assay for compound screening and profiling via fluorescence-based quantification of enzyme activity.
Target Overview
CAT#
TMPRSS2
Enzyme
Human TMPRSS2
Synonym
Transmembrane protease serine 2, Serine protease 10, PRSS10, TMPS2
Substrates
Fluorogenic peptide [Boc-Gln-Ala-Arg-AMC], 25 µM
Assay Properties
Readout
Enzymatic activity
Reference Compound IC50s
| Compounds | IC50 (nM) |
|---|---|
| Nafamostat Mesylate | 0.024 |
| Camostat Mesylate | 0.31 |
| FOY 251 | 7.6 |
| Gabexate Mesylate (GM) | 25 |
| Bromhexine hydrochloride (BHH) | >100,000 |
Scientific Information
Screening Location
Malvern, PA, USA
Further information
More information can be found on our website Protease Assay Services.
Reference compound IC50 for TMPRSS2
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