TRKA (G595R/G667S) Kinase Assay Service

Activity-based TRKA (G595R/G667S) kinase assay for compound screening and profiling via radiometric HotSpot^TM kinase assay.

Target Overview

CAT#

TRKA (G595R/G667S)

Enzyme

Human TRKA (G595R/G667S)

HGNC

NTRK1 (G595R/G667S)

Synonym

MTC, TRK, TRK1

Substrates

Peptide substrate, poly[Glu:Tyr] (4:1), 0.2 mg/ml
ATP 10 µM

Assay Properties

Reaction

Substrate + [γ-³³P]-ATP = ³³P-Substrate + ADP

Readout

Enzymatic activity

Reference Compound IC50s

Scientific Information

P04629 (http://www.uniprot.org/uniprot/P04629)

Screening Location

Malvern, USA

Reference compound IC50 for TRKA (G595R/G667S)