TRKC (G623E) Kinase Assay Service

Activity-based TRKC (G623E) kinase assay for compound screening and profiling via radiometric HotSpot^TM kinase assay.

Target Overview

CAT#

TRKC (G623E)

Enzyme

Human TRKC (G623E)

HGNC

NTRK3 (G623E)

Synonym

GP145-TrkC

Substrates

Peptide substrate, poly[Glu:Tyr] (4:1), 0.2 mg/ml
ATP 10 µM

Assay Properties

Reaction

Substrate + [γ-³³P]-ATP = ³³P-Substrate + ADP

Readout

Enzymatic activity

Reference Compound IC50s

Scientific Information

Q16288 (http://www.uniprot.org/uniprot/Q16288)

Screening Location

Malvern, USA

Reference compound IC50 for TRKC (G623E)