Activity-based TRKC kinase assay for compound screening and profiling via 33PanQinaseTM – assay technology
Target Overview
RBE Target ID
TRKC
Enzyme
Human TRKC, wt
HGNC
NTRK3
Manning ID
TRKC
Synonym
TRK-C, TRKC, Trk-C, gp145, NTRK3, GP145-TrkC
UniProt
Q16288 (NTRK3_HUMAN)
Kinase Type
Protein kinase
Kinase Group
TK
Assay Properties
Assay Format
33PanQinaseTM
Substrates
PolyEY, ATP
Reaction
PolyEY + 33P-ATP = 33P-PolyEY + ADP
Readout
Enzymatic activity
Technical Reference Compound IC50 value(s)
| Compounds | IC50 (nM) |
|---|---|
| Staurosporine | 4 |
| Sorafenib | 1000 |
| Sunitinib | 130 |
Screening Location
Freiburg, Germany
Further Information
More information can be found on our website Kinase Assays
Service and Product Availability
Screening Opportunities
| FreeChoice | TRKC |
| 355 wt Profiler | Yes |
| 355 IC50 wt Profiler | Yes |
| Mutant Profiler Addon | No |
| Lipid Kinase Profiler Addon | No |
| IC50 Profiler | No |
Recombinant Protein Availability
| Active recombinant protein | Yes; ProQinaseTM – TRKC (Activity verified by 33PanQinaseTM-Assay) |
| Product Number | 0775-0000-1 |
| Web Shop | Reaction Biology Online Shop |
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