Activity-based TRKC kinase assay for compound screening and profiling via radiometric HotSpotTM kinase assay.
Target Overview
CAT#
TRKC
Enzyme
Human TRKC
HGNC
NTRK3
Synonym
GP145-TrkC
Substrates
Peptide substrate, poly[Glu:Tyr] (4:1), 0.1 mg/ml
ATP 10 µM
ATP 10 µM
Assay Properties
Reaction
Substrate + [γ-33P]-ATP = 33P-Substrate + ADP
Readout
Enzymatic activity
Reference Compound IC50s
Scientific Information
Q16288 (http://www.uniprot.org/uniprot/Q16288)
Screening Location
Malvern, USA
Reference compound IC50 for TRKC
